Item Type | Name |
Concept
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Oncogene Proteins, Fusion
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Concept
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Proto-Oncogene Protein c-fli-1
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Concept
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Oncogene Protein p21(ras)
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Concept
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Oncogene Proteins
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Concept
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Genes, ras
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Concept
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Proto-Oncogene Proteins c-akt
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Concept
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Proto-Oncogene Proteins c-vav
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Concept
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ras Proteins
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Concept
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Proto-Oncogene Proteins c-cbl
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Concept
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Proto-Oncogene Proteins p21(ras)
|
Concept
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Proto-Oncogene Proteins
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Academic Article
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axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.
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Academic Article
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Expression of axl, a transforming receptor tyrosine kinase, in normal and malignant hematopoiesis.
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Academic Article
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The transforming receptor tyrosine kinase, Axl, is post-translationally regulated by proteolytic cleavage.
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Academic Article
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Rek, a gene expressed in retina and brain, encodes a receptor tyrosine kinase of the Axl/Tyro3 family.
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Academic Article
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The src homology 2 and phosphotyrosine binding domains of the ShcC adaptor protein function as inhibitors of mitogenic signaling by the epidermal growth factor receptor.
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Academic Article
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Differential regulation of SHC proteins by nerve growth factor in sensory neurons and PC12 cells.
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Academic Article
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Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity.
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Academic Article
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Intersectin, an adaptor protein involved in clathrin-mediated endocytosis, activates mitogenic signaling pathways.
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Academic Article
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Intersectin can regulate the Ras/MAP kinase pathway independent of its role in endocytosis.
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Academic Article
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Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK.
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Academic Article
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The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/peripheral primitive neuroectodermal tumors.
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Academic Article
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Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling.
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Academic Article
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Regulation of neuron survival through an intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway.
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Academic Article
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Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction.
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Academic Article
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A new dimension to Ras function: a novel role for nucleotide-free Ras in Class II phosphatidylinositol 3-kinase beta (PI3KC2?) regulation.
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Academic Article
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Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase.
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Academic Article
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Phosphatidylinositol 3-kinase, class 2 beta (PI3KC2?) isoform contributes to neuroblastoma tumorigenesis.
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Academic Article
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Intersectin scaffold proteins and their role in cell signaling and endocytosis.
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Academic Article
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Inhibition of RAS function through targeting an allosteric regulatory site.
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Academic Article
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Targeting the a4-a5 interface of RAS results in multiple levels of inhibition.
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Academic Article
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Direct inhibition of RAS: Quest for the Holy Grail?
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Academic Article
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Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus.
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Academic Article
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Pharmacological targeting of RAS: Recent success with direct inhibitors.
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Academic Article
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Targeting the a4-a5 dimerization interface of K-RAS inhibits tumor formation in vivo.
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Academic Article
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Correction: Targeting the a4-a5 dimerization interface of K-RAS inhibits tumor formation in vivo.
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Academic Article
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Therapeutic targeting of RAS: New hope for drugging the "undruggable".
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Academic Article
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Biology, pathology, and therapeutic targeting of RAS.
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Academic Article
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Selective and noncovalent targeting of RAS mutants for inhibition and degradation.
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Academic Article
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Probing RAS Function with Monobodies.
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Academic Article
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Targeting the KRAS a4-a5 allosteric interface inhibits pancreatic cancer tumorigenesis.
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Academic Article
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Inhibition of RAS: proven and potential vulnerabilities.
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Academic Article
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Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK pathway.
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Academic Article
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Targeting the "undruggable" RAS with biologics.
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Academic Article
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Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants.
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Academic Article
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Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket.
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Academic Article
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Mutations in the a4-a5 allosteric lobe of RAS do not significantly impair RAS signaling or self-association.
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